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KMID : 1140420220310030254
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Journal of Obesity & Metabolic Syndrome
2022 Volume.31 No. 3 p.254 ~ p.262
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Adherence to and Dropout from Liraglutide 3.0 mg Obesity Treatment in a Real-World Setting
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Ko Hae-Jin
Kim Jin-Wook
Lim Soo
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Abstract
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Background: The factors associated with non-adherence to obesity treatment using liraglutide 3.0 mg in a real-world setting remain elusive.
Methods: We performed a secondary data analysis of 769 participants treated with liraglutide 3.0 mg from December 2017 to June 2020 at nine Korean hospitals. Data were collected 2, 4, and 6 months after treatment initiation. Adherence groups were defined as <2, 2?4, 4?6, and ≥6 months.
Results: Among the 769 patients, 539 (70.1%) were lost to follow-up within 6 months because of unknown reasons (54.2%), adverse events (14.8%), change of treatment (13.7%), or discontinuation due to poor weight loss (9.3%). Dropout at 6 months was significantly associated with the presence of diabetes mellitus in step 1 and the presence of diabetes mellitus with regular exercise in step 2 of the logistic regression analysis using the forward stepwise selection method. After adjusting for covariates, the presence of diabetes mellitus (odds ratio [OR], 0.25; 95% confidence interval [CI], 0.10?0.63; OR, 0.47; 95% CI, 0.31?0.73; and OR, 0.52; 95% CI, 0.34?0.80) and regular exercise (OR, 2.86; 95% CI, 1.31?6.23; OR, 2.09; 95% CI, 1.26?3.48; and OR, 2.99; 95% CI, 1.81?4.92) showed significant associations in the <2, 2?4, and 4?6 groups compared with the highest adherence group (≥6 months).
Conclusion: Non-adherence to obesity treatment with liraglutide is related to regular exercise and absence of diabetes mellitus. Further prospective studies are warranted to increase medication adherence in those groups.
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KEYWORD
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Diabetes mellitus, Exercise, Lost to follow-up, Liraglutide, Medication adherence
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